Polynucleotide
Polynucleotides (PN) are a cutting-edge regenerative treatment rapidly gaining popularity in aesthetic medicine. These biocompatible DNA fragments, commonly extracted from salmon or trout sperm, act as tissue regenerators and bio-stimulators. By enhancing cellular repair, improving hydration, and stimulating collagen production, PNs help restore skin quality at a cellular level.
Also known as PDRN (Polydeoxyribonucleotide), this treatment promotes skin rejuvenation, healing, and regeneration, making it an advanced solution for aging, damaged, or dull skin.
3-4 sessions
needed
1 year
duration of results
Benefits of Polynucleotides
How do Polynucleotides work?
Polynucleotides act as powerful bio-stimulators, triggering natural repair and regeneration at a cellular level. Once introduced into the skin, they promote angiogenesis (formation of new blood vessels), stimulate fibroblast activity, and enhance collagen and elastin production. This improves tissue hydration, elasticity, and skin metabolism, leading to smoother, firmer, and healthier skin. PN also accelerates wound healing and restores balance to damaged or aging tissue.
What happens during the procedure?
The treatment is administered through intradermal injections with fine needles, targeting specific areas of concern such as the face, under-eyes, neck, or scalp. In some cases, PN is combined with microneedling or radiofrequency for enhanced penetration and results. A typical session lasts 15–30 minutes, with minimal discomfort.
Following the procedure, patients may experience mild redness or swelling, which usually subsides within 24–48 hours, allowing a quick return to daily activities.
Is there downtime after the procedure?
Downtime is minimal. Mild redness, swelling, or small injection marks may appear immediately after treatment but usually resolve within 24–48 hours. Normal activities can be resumed right away.
Are Polynucleotides safe?
Yes. PN is derived from highly purified salmon or trout DNA fragments, making it biocompatible and safe for skin use. The treatment is well-tolerated with a low risk of allergic reaction or side effects.
Can Polynucleotides be combined with other treatments?
Absolutely. PN pairs well with microneedling, radiofrequency, laser, or dermal fillers, enhancing results and accelerating tissue repair.
Which is better: PRP or PN?
Both are effective regenerative options. PRP is better for natural healing and patients who prefer autologous (from their own blood) treatments. PN is often favored for skin texture, elasticity, and hydration improvements, with longer-lasting regenerative effects. Many clinics recommend a combination for best results.
Are Polynucleotides better than Botox?
They work very differently. Botox temporarily relaxes muscles to smooth expression lines, while PN rejuvenates skin at the cellular level by repairing tissue, improving hydration, and reducing fine lines over time. Botox gives faster visible results for wrinkles, whereas PN provides long-term skin quality improvements. Many patients choose to combine both treatments for comprehensive anti-aging.
Why Dr. Amna’s?
Dr. Amna is a board-certified aesthetic physician (AAAM) specializing in skin aesthetics with advanced training from world-renowned experts including Dr. Mucio Porto for facial rejuvenation and Dr. Kaon, the inventor of advanced thread techniques in South Korea. With master certifications in fillers, Botox, and thread lifting from prestigious institutions like AAAM, Hugel, and Sinclair Academy, plus co-authorship of “The Face in Harmony: A Rejuvenation Encyclopedia,” she brings unparalleled expertise to non-surgical facial contouring. Her comprehensive understanding of facial anatomy and balance, combined with regular attendance at international conferences like IMCAS and EADVS, ensures natural-looking skin results that enhance your unique beauty using only FDA-approved products and internationally recognized techniques.
Ready to get started?
Considering Polynucleotide treatment? Start by booking a consultation with Dr. Amna to determine if this is the best treatment for your concerns.